AMD-070 Hydrochloride - CAS# 880549-30-4 Size:Solid 2 mg Cdk7 from Cdk7as/as or Cdk7+/+

Cdk7 from Cdk7as/as or Cdk7+/+ cells is immunoprecipitated and tested its kinase activity towards both a Pol II CTD-containing fusion protein (GST-CTD) and human Cdk2

InChiKey: PKXWXXPNHIWQHW-RCBQFDQVSA-N

CAS Number: 1991986-30-1

1030846-42-4

PubMed PMID: 21620683

AMD-070 Hydrochloride - CAS# 880549-30-4 Size:Solid 2 mg Cdk7 from Cdk7as/as or Cdk7+/+Mavorixafor, also known as AMD11070, AMD070, X4P 001, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF 1 ligand binding (IC50 = 12. 5 1. 3 nM), inhibits SDF 1 mediated calcium flux (IC50 = 9. 0 2. 0 nM) and SDF 1 mediated activation of the CXCR4 receptor as measured by a Eu GTP binding assay (IC50 =39. 8 2. 5 nM) or a [(35)S] GTPS binding assay (IC50 =19. 0 4. 1 nM), and inhibits SDF 1 stimulated chemotaxis (IC50