LY2603618 alog-1 PubMed PMID: 17633123

PubMed PMID: 17633123

Addition of 10 μM 1-NM-PP1 retards G1/S progression by the mutant but not the wild-type cells

Chanan-Khan A

CAS Number: 243984-10-3

Eliminating cells gone astray

LY2603618 alog-1 PubMed PMID: 17633123Rabusertib, also known as LY2603618, is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP dependent serine threonine kinase, is a key component in the DNA replication monitoring checkpoint