GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 5-2 µM final concentration in

5-2 µM final concentration in vitro and in cellular assays

TAE684 inhibits STAT3 and STAT5 phosphorylation in a dose-dependent manner in both Ba/F3 NPM-ALK and Karpas-299 cells

in the pore of the cystic fibrosis transmembrane conductance regulator

Aragon-Ching JB

CUDC-907 was used at 0

GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 5-2 µM final concentration inGS143, CAS No. 916232 21 8, is selective TrCP1 ligase inhibitor, inhibits IB ubiquitination with IC50 ~5. 2 M without affecting proteasome activity. It blocks LPS induced expression of inflammatory cytokines in human myelomonocytic cells. It suppresses antigen induced NFB expression, inflammation and mucus production in airways of OVA sensitized mice. Product information CAS Number: 916232 21 8 Molecular Weight: 466. 46 Formula: C28H19FN2O4 Chemical