ZLN005 - PGC-1α Transcriptional Activator. CAS# 49671-76-3 60135 Sacubitril (AHU-377)(tmax 0

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ZLN005 - PGC-1α Transcriptional Activator. CAS# 49671-76-3 60135 Sacubitril (AHU-377)(tmax 0ZLN005, CAS No. 49671 76 3, is a potent and selective small molecule PGC 1 transcriptional activator. It stimulates the expression of PGC 1 and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation. Chronic oral administration of ZLN005 at 15 mg kg per day to diabetic db db mice increased PGC 1 and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance,

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