SUV91 Polyclonal Antibody, 20ul Petri Dishes NRF1 encodes a protein that

NRF1 encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration

A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration

Three alternatively spliced variants that encode different protein isoforms have been described

Unleash the power of Nb

Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype

SUV91 Polyclonal Antibody, 20ul Petri Dishes NRF1 encodes a protein thatThis gene encodes an evolutionarily conserved protein containing an N terminal chromodomain and a C terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.