I10R2 Polyclonal Antibody, 20ul Culture Media Reduced expression of this protein

Reduced expression of this protein has been implicated in cardiomyopathies

This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain

The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins

including a metalloproteinase domain

forms a heterodimeric complex with another receptor protein

I10R2 Polyclonal Antibody, 20ul Culture Media Reduced expression of this proteinThe protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10 induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.