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ULK3 Polyclonal Antibody, 100ul Thermal Control Mutations in this gene are

SKU: 7103030416

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ULK3 Polyclonal Antibody, 100ul Thermal Control Mutations in this gene areSerine threonine protein kinase which enhances GLI1 and GLI2 transcriptional activity and consequently positively regulates GLI dependent SHH signaling. May exert this function by promoting GLI1 nuclear localization. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.

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Description

Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN7)

and the transcription factors ATF2 (activating transcription factor 2) and c-JUN

which has been shown to function as an adhesion recognition signal for several integrins

The tripartite motif containing 3 encoded by TRIM3 is a member of the tripartite motif (TRIM) family

A read-through INS-IGF2 gene exists| whose 5' region overlaps the INS gene and the 3' region overlaps this gene

ULK3 Polyclonal Antibody, 100ul Thermal Control Mutations in this gene areSerine threonine protein kinase which enhances GLI1 and GLI2 transcriptional activity and consequently positively regulates GLI dependent SHH signaling. May exert this function by promoting GLI1 nuclear localization. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.

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