PERK Monoclonal Antibody, 100ul In vitro Assessment The heterodimeric receptor is involved

The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis

Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway

Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase

Alternatively spliced transcript variants encoding different isoforms have been found for TP53I3

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily

PERK Monoclonal Antibody, 100ul In vitro Assessment The heterodimeric receptor is involvedThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in