Phospho-BRCA1 (S1423) Polyclonal Antibody, 20ul Diagnostic Probes & Oligos It may interact with various

It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase

which comprises about 25% of total cases

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They physically associate with both proteasomes and ubiquitin ligases

Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported

Phospho-BRCA1 (S1423) Polyclonal Antibody, 20ul Diagnostic Probes & Oligos It may interact with variousBRCA1 (BRCA1, DNA repair associated) encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi subunit protein complex known as the BRCA1 associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C terminal