ESX1 Rabbit Polyclonal Antibody, 100ul Peripheral Blood Separation Tube sequence-specific DNA binding and transcriptional

sequence-specific DNA binding and transcriptional activator activity

regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth

suggesting a role in tumor development and metastasis

A similar duplicated gene is located next to this gene on chromosome 16

Unlike most of the SWI/SNF complex proteins

ESX1 Rabbit Polyclonal Antibody, 100ul Peripheral Blood Separation Tube sequence-specific DNA binding and transcriptionalThis gene encodes a dual function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N terminal fragment with a paired like homeodomain and a 20 kDa C terminal fragment with a proline rich domain. The C terminal fragment localizes to the cytoplasm while the N terminal fragment localizes exclusively to the nucleus. In contrast to human the mouse homolog has a novel PN PF motif in the C terminus and is paternally imprinted in