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RB6I2 Polyclonal Antibody, 20ul Biomatrix NFKB1 appears to have dual

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RB6I2 Polyclonal Antibody, 20ul Biomatrix NFKB1 appears to have dualThe protein encoded by this gene is a member of a family of RIM binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10; 12)(q11; p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants.

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Description

NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing

A pseudogene has been identified on the Y chromosome

Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing| this protein may be involved in the repair of double strand DNA breaks

Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity

the main pungent ingredient in hot chili peppers

RB6I2 Polyclonal Antibody, 20ul Biomatrix NFKB1 appears to have dualThe protein encoded by this gene is a member of a family of RIM binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10; 12)(q11; p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants.

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